Tags: #notes
Links: https://www.youtube.com/watch?v=0oNzASdSrxk

Toxins

intefere with movement, demobilizing is important
affect aceytolcholine, movmement sotps without it
Saren gas inhibits ACHe, enzxyme that breaks down ACH in synaptic gap. Muscles are either over stim or paralyzed, including those needed for breathing

Myastheia Gravis

• Autoimmune disease, targets nicotinic ac receptors
• degeneration effects head first, droopy eyelids and slurred speech
• meds and removal of timus gland helps

Muscular Dystrophy

about 340 disaese

• relate to genetic problems with distrophen ,protec brain from injury
• most severe, dushen, is caused by complete lack of it
• muscle cells break down as a resuklt of normal movement, causing scarring
• substitue heathy genes helps

Polio

only attack human

• selectively attacks spinal alpha motor
• muscle weakness and paralysis of legs are most typicak
• damage can affect breathing
• iron lung
• effective vaccines exist, war and poverty keep it alive

Spinal Injury

• affects 500k globally
• traffic accidents, falls, violence
• epidural stim couples with training improves patient mobility

ALS, Amyotrophic Lateral Sclerosis

unknown cause

• results from degen of motor neurons in brain stem, spine, and motor cortex
• genetic seem to play a role
• environmental causes to plan
• social media icebucket challenge raised fund for more research
• proud of steve saling, son in laws cousin,
  • attendd research conferences, build living system for those with als in boston

parkenson disease

progressive loss of vol. movement,

• Begins with degen of dopinergic in the sunbstantinigra, progrss to higher motor systems
• genetic vulnerability
• environmental views more problematic
• possibly that it origininates in gut
• leads to over producing of alpha cynucleun proteins,
• involve dompaine agonist
• patients achieve good results with deep brain stimulation

Huntington Disease

• Genetic Conditiion
• no escape
• Copy number variation, one codon, for one amino accid on the HTT gene on Chromosome 4, between 6 and 100, with exactly 37 or more repeats have hunington disaese
• jerky dance like movements
• cognitive symptoms, depressiom ,delusion, halucination
• happens in midlife
• Treatments aimed at preserving quality of life
• genetic therapys might provide some relief